Endocrine Abstracts

Introduction: The aim of the study was to examine the risk factors associated with diabetic retinopathy (DR) in adult patients with DM1 and DM2.Design: The study group consisted of adults patients with DM1 and DM2, diagnosed according to the WHO criteria. Risk factors for diabetic retinopathy were evaluated on the demographic data, medical history, clinical and biochemical parameters related to metabolic control of diabetes. We collected also ophthalmic ...

Introduction: The aim of the study was to assess antropometric and metabolic parametres in women with previous gestational diabetes mellitus (GDM) during a 30-month observation.Design: Our prospective study cohort consisted of 367 women with GDM diagnosed according to WHO criteria. Oral glucose tolerance test (OGTT) was performed during 6-10 weeks and 12, 18, 24, 30 months after delivery. On every 6th month between 12th and 30th month after delivery we e...

Adrenocortical carcinoma (ACC) is a rare and very aggressive tumor with poor prognosis. The aim of the study was to identify prognostic factors of recurrence-free (RFS) and overall survival (OS) in patients with ACC.We present a retrospective analysis in 52 patients diagnosed with ACC. A number of factors both histological and clinical were analyzed. Recurrent disease was defined as a new lesion confirmed in imaging. Kaplan-Meier method and multivariate ...

Aim: Aim of our study was to compare: the baseline and metoclopramide induced prolactin plasma level between PCOS women with FAI <5 phenotype (group A)(FAI, total testosterone divided by sex hormone biding globulin, whole multiply by 100) and PCOS women with FAI>5 phenotype (group B).Patients and methods: The study population consisted of 354 lean women with PCOS. In all the patients the prolactin level at 02:00 h, 08:00 h and during the metoclop...

Women with Polycystic Ovary Syndrome (PCOS) are at increased risk of developing insulin resistance, obesity and dyslipidemia, however obesity per se does not explain the higher incidence of insulin resistance in PCOS women when compared to the general population. Altered adipose tissue morphology and function may be a central factor contributing to metabolic disturbances in PCOS. Using a clinically realistic ovine model of PCOS we reported hyperinsulinaemia and early ...

Brown adipose tissue metabolism is of remarkable pathophysiological interest, because it could be a target for future therapies for obesity and metabolic syndrome. Irisin (Ir), recently identified novel adipomyokine is essential in a white-to-brown fatty tissue transdifferentiation, and mediates some of the positive influences on metabolic disorders through increase of energy expenditure. The exact regulation of Ir secretion and action is unknown but significant positive assoc...

Introduction: The aim of the study was to assess if gestational diabetes mellitus (GDM) influence the pregnancy outcomes and the growth patterns in children.Design: Our prospective study cohort consisted of 261 children born to mothers with GDM and 153 control children born to non-diabetic mothers. In both groups children’s weight, length were assessed. Children were matched for large for gestational age (LGA) (birth weight >90th percentile for ...

Objectives: Glucocorticoids (GCs) intervene in different physiological activities in almost all systems of the human organism. However, GCs are also potent inducers of apoptosis in many cell types and tissues. It is known, that glucocorticoid-induced apoptosis affects the musculoskeletal system, circulatory system, nervous system, endocrine system, reproductive system, and the immune system. Nevertheless, the exact mechanisms of GCs action in human normal hematopoiesis are sti...

Introduction: TSH seems to play direct role in bone metabolism. TSH receptors are expressed on osteoblasts and osteoclast precursors. Osteocalcin (OC) is well known marker of bone formation, whereas collagen type I crosslinked C-telopeptide I (CTX) is marker of bone resorption. Sclerostin is a protein, recently found to inhibit bone formation, while parathormone (PTH) inhibits sclerostin production. The aim of the study was to estimate sclerostin, OC, CTX and PTH levels after ...

Introduction: In pregnant women there is a twofold increase in synthesis of calcitriol, i.e. the active metabolite of vitamin D. Literature data point to adverse effects of vitamin D deficiency during pregnancy both for pregnant woman and foetus. Polish data on the effects of vitamin D deficiency in this group are scarce.Aim of the study: The aim of this study was to evaluate the relationship between vitamin D3 concentrations in pregnant women on health ...